ABSTRACT
This study was performed to evaluate the efficacy of 1-Butyl-3-[2E-3-[dimethylamino] prop-2 enoyl] 4-hydroxyquinoline-2 [IH]-one [BDHQ] when given to hamsters after infection with Schistosoma haematobium [350 +/- 50 cercariae/hamster]. The drug was prepared as an aqueous suspension by suspending 100, 150, 200 mg in 10 mI of vehicle for each hamster [mg/kg body weight]. Praziquantel was prepared as an aqueous suspension by dissolving 150 mg of the vehicle to estimate the schistosomal worms and ova/tissues were counted in the hepatic and intestinal tissues. The data of the present work revealed that the percentage reduction in number of worms recovered after oral administration of [BDHQ] ranged between 40% and 98% when compared with the control. As regards the worm burden and distribution, the percent of worms recovered from the liver was ranged between 21% and 50%. While those recovered from portomesentric veins reached 70% to 98%. Beside during in vivo study, the effect of oral administrate of hydroxy quinoline [BDHQ] on ova tissue count of Schistosoina hac'matobiu, n. The number of ova per gram tissue is also an important criterion for the evolution of both magnitude of infection and efficacy of antischistosomal agents. In this study when the infected hamster treated with [BDHQ] at a dose of 100mg/kg body weight. Tissue egg count significantly decline by 40.2% in intestine, six weeks after treatment, moreover the tissue egg count significantly declined by 43.9% in liver and 40.2% intestine, when the infected hamster were treated with BDHQ at a dose 150mg/kg b.w. beside at dose 200mg/kg b.w, the percentage reduction in ova count unchanged significantly when compared with PZQ treated hamsters which represented by 60% in number of ova count